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Syncapone 100 Tablet (Levodopa 100mg+ Carbidopa 25mg+ Entacapone 200mg))
Syncapone 100 Tablet combines levodopa 100 mg, carbidopa 25 mg, and entacapone 200 mg to provide continuous dopamine replacement for Parkinson’s disease. Available through HealthyRXS with price varying by retailer, it is designed for patients who experience motor fluctuations on standard levodopa therapy and need smoother symptom control.
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Key features
- Levodopa 100 mg – primary dopamine precursor for motor control.
- Carbidopa 25 mg – blocks peripheral conversion, reduces nausea.
- Entacapone 200 mg – COMT inhibitor that extends levodopa’s effect.
- Fixed-dose tablet – combines three agents in one pill.
- Film-coated – easy swallow, moisture-resistant.
- 30-tablet blister pack – protects tablets and supports daily dosing.
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Pros
- +Improves levodopa plasma stability, reducing motor fluctuations.
- +Simplifies regimen by merging three drugs into one tablet.
- +Reduces peripheral side-effects thanks to carbidopa.
- +Convenient blister packaging for daily use.
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Cons
- −May cause dyskinesia or other levodopa-related side effects.
- −Not suitable for patients with narrow-angle glaucoma.
- −Requires prescription; price varies by pharmacy.
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About Syncapone 100 Tablet (Levodopa 100mg+ Carbidopa 25mg+ Entacapone 200mg))
What is Syncapone 100 Tablet (Levodopa 100mg+ Carbidopa 25mg+ Entacapone 200mg))?
Syncapone 100 Tablet is a fixed-dose combination of three agents that target the core pathophysiology of Parkinson’s disease. Levodopa serves as the primary dopamine precursor, while carbidopa inhibits peripheral decarboxylation, increasing central availability and reducing nausea. Entacapone adds a reversible inhibition of catechol-O-methyltransferase (COMT), extending levodopa’s plasma half-life and flattening peak-to-trough fluctuations. The 100 mg/25 mg/200 mg ratio is calibrated for patients who have progressed beyond monotherapy and require a more stable dopaminergic profile. Manufactured under Good Manufacturing Practice standards, the tablets are film-coated, swallow-able, and packaged in blister packs of 30 units for convenient dosing.
Key features
- Levodopa 100 mg – primary dopamine precursor for motor symptom relief.
- Carbidopa 25 mg – blocks peripheral conversion, reducing nausea and increasing brain availability.
- Entacapone 200 mg – COMT inhibitor that prolongs levodopa action and smooths plasma peaks.
- Fixed-dose tablet – simplifies regimen compared with separate agents.
- Film-coated – easy to swallow, resistant to moisture, and stable for up to two years.
- 30-tablet blister pack – supports daily dosing and protects against contamination.
Who is Syncapone 100 Tablet (Levodopa 100mg+ Carbidopa 25mg+ Entacapone 200mg)) for?
Syncapone 100 Tablet is intended for adults diagnosed with Parkinson’s disease who experience “wearing-off” phenomena or motor fluctuations despite standard levodopa therapy. It is particularly useful for patients who need a single tablet to deliver both dopamine precursor and COMT inhibition, reducing pill burden. Clinicians may prescribe it after evaluating renal function and concomitant medications, as entacapone can interact with certain drugs. The formulation is not recommended for individuals with narrow-angle glaucoma or known hypersensitivity to any component.
How does Syncapone 100 Tablet (Levodopa 100mg+ Carbidopa 25mg+ Entacapone 200mg)) compare?
Compared with levodopa-carbidopa alone, Syncapone adds a COMT inhibitor, which can reduce the frequency of dosing from three to four times daily to a more manageable schedule. Relative to separate entacapone tablets, the fixed-dose combination eliminates the need for multiple prescriptions and improves adherence. However, it still shares the same contraindications as its individual components and may cause similar side-effects such as dyskinesia, diarrhea, or urine discoloration. Patients should discuss dosage adjustments with their neurologist.
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Best use cases
- →Managing “wearing-off” episodes in mid-stage Parkinson’s.
- →Reducing dosing frequency for patients on multiple levodopa tablets.
- →Stabilizing motor symptoms after levodopa-carbidopa alone becomes insufficient.
- →Simplifying medication schedule for home-bound seniors.
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Is Syncapone 100 Tablet (Levodopa 100mg+ Carbidopa 25mg+ Entacapone 200mg)) right for you?
Syncapone 100 Tablet is best suited for adults with Parkinson’s disease who have progressed beyond basic levodopa-carbidopa therapy and experience motor fluctuations. Ideal for patients seeking a single-pill solution that adds COMT inhibition, it requires a physician’s prescription and routine monitoring of liver function. Compare it with separate levodopa-carbidopa and entacapone tablets to assess cost and convenience. Alternatives include extended-release levodopa formulations or other COMT inhibitors, but Syncapone offers a balanced dose for many mid-stage patients.
How it compares: Compared with separate levodopa-carbidopa tablets, Syncapone adds a COMT inhibitor, cutting dosing frequency and improving symptom steadiness. Relative to extended-release levodopa products, it provides a quicker onset but may require more frequent dosing. Overall, the fixed-dose combo offers a middle ground between standard tablets and long-acting formulations for patients needing both dopamine replacement and COMT blockade.
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Frequently Asked Questions
What is the purpose of adding entacapone to levodopa/carbidopa therapy?
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Entacapone inhibits the enzyme catechol-O-methyltransferase (COMT), which otherwise metabolizes levodopa in the periphery. By blocking this pathway, entacapone prolongs levodopa’s plasma half-life, leading to more consistent dopamine levels and fewer “wearing-off” periods for patients who no longer achieve stable control with levodopa-carbidopa alone.
Does Syncapone 100 Tablet require any dietary restrictions?
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Syncapone does not mandate a strict diet, but protein-rich meals can compete with levodopa for intestinal absorption, potentially reducing its effectiveness. Physicians often advise patients to take the tablet with a low-protein snack or to separate levodopa dosing from high-protein meals by at least 30 minutes. Consistent timing helps maintain stable plasma levels.
How often should the tablet be taken?
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Syncapone 100 Tablet is typically prescribed to be taken three to four times daily, spaced evenly throughout the waking hours. The exact schedule depends on individual symptom patterns and the physician’s assessment. Patients should follow the dosing instructions on the prescription label and avoid missing doses, as irregular intake can trigger motor fluctuations.
Is Syncapone safe for patients with liver impairment?
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Entacapone is metabolized primarily in the liver, so patients with moderate to severe hepatic impairment may experience higher plasma concentrations and an increased risk of side effects. Clinicians usually start at a lower dose and monitor liver function tests closely. For severe liver disease, alternative therapies without a COMT inhibitor are often preferred.
Can Syncapone be used together with other Parkinson’s medications?
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Syncapone can be combined with other Parkinson’s agents such as MAO-B inhibitors, dopamine agonists, or amantadine, provided the prescribing neurologist evaluates potential drug interactions. The addition of a COMT inhibitor may increase levodopa exposure, so dose adjustments of concurrent levodopa-based products are often necessary. Regular follow-up ensures optimal symptom control and minimizes adverse effects.
Is Syncapone 100 Tablet (Levodopa 100mg+ Carbidopa 25mg+ Entacapone 200mg)) in stock at HealthyRXS?
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Yes, Syncapone 100 Tablet (Levodopa 100mg+ Carbidopa 25mg+ Entacapone 200mg)) is currently in stock at HealthyRXS.
Are there coupon codes for HealthyRXS?
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Yes — Love Those Deals currently tracks 4 active HealthyRXS coupons. See the coupons section on this page to copy a code before checkout.
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Specifications
- Category
- Medical
- SKU
- 4077
Last updated May 14, 2026