Sorifix Ointment (Calcipotriol 0.005% w/w + Clobetasol 0.05% w/w)

What is Sorifix Ointment (Calcipotriol 0.005% w/w + Clobetasol 0.05% w/w)?

Sorifix Ointment is a topical prescription medication containing two active ingredients: calcipotriol (0.005% w/w), a synthetic vitamin D analog, and clobetasol propionate (0.05% w/w), a high-potency corticosteroid. This combination works synergistically to reduce skin cell overproduction and inflammation associated with plaque psoriasis. It is formulated as an ointment base, which provides enhanced moisturization and better adherence to thick, scaly plaques compared to creams or lotions.

Key features

• Dual-Action Formula — Combines calcipotriol and clobetasol to target both hyperproliferation and inflammation in psoriatic lesions.
• High-Potency Steroid — Clobetasol 0.05% is among the strongest topical corticosteroids available for dermatological use.
• Ointment Base — Occlusive formulation improves penetration and reduces scaling, especially on dry, cracked skin.
• Targeted Psoriasis Relief — Designed specifically for stable plaque psoriasis on the body, including elbows, knees, and scalp.
• Short-Term Use — Recommended for limited-duration therapy to minimize steroid-related side effects.
• Prescription-Only — Requires medical supervision due to potency and systemic absorption risks.
• Fixed-Dose Combination — Simplifies regimen by delivering two therapies in one application.

Who is Sorifix Ointment (Calcipotriol 0.005% w/w + Clobetasol 0.05% w/w) for?

This ointment is intended for adults with moderate to severe plaque psoriasis who require stronger therapy than single-agent treatments. It is particularly beneficial for patients with thick, stubborn plaques unresponsive to milder corticosteroids or vitamin D analogs alone. Not recommended for facial, intertriginous, or genital areas due to risk of atrophy. Use should be supervised by a dermatologist, especially in pediatric or long-term cases.

How does Sorifix Ointment (Calcipotriol 0.005% w/w + Clobetasol 0.05% w/w) compare?

Compared to standalone corticosteroids, Sorifix offers added benefit of calcipotriol, which helps normalize skin cell growth and may reduce relapse rates. It outperforms low-potency steroids in clearing plaques faster but carries higher risk of local side effects. Versus other combination products, it matches clinical efficacy but differs in base formulation—its ointment form suits very dry skin better than creams. It is not interchangeable with non-steroidal topicals like calcineurin inhibitors, which are safer for sensitive areas but less potent.